Sulfamoyl-substituted phenethylamine derivatives and process of producing them

ABSTRACT

Novel sulfamoyl-substituted phenethylamine derivatives which exhibit α-adrenergic blocking action and are useful as an antihypertensive agent and an agent for the treatment of congestive heart failure.

BACKGROUND OF THE INVENTION

1. Field of the Invention

This invention relates to novel sulfamoyl-substituted phenethylamine derivatives and the acid addition salts thereof, and more particularly, to novel sulfamoyl-substituted phenethylamine derivatives and the acid addition salts thereof which exhibit a strong α-adrenergic blocking action and are useful as an antihypertensive agent and a treating agent for congestive heart failure. The invention is further concerned with the process of producing these derivatives and the acid additon salts thereof.

2. Description of the Prior Art

British Pat. No. 2,006,772 discloses a series of compounds exhibiting α- and β-adrenergic blocking actions and also the patent discloses that the compound shown by the following formula exhibits strong α- and β-adrenergic blocking actions ##STR1##

U.S. Pat. No. 3,860,647 discloses a series of compounds shown by the following general formula ##STR2## wherein R represents hydrogen or alkyl having 1-4 carbon atoms; R' represents alkyl having 1-6 carbon atoms, cycloalkyl having 3-6 carbon atoms, XC₆ H₄ (CH₂)₂ CH(CH₃), XC₆ H₄ (CH₂)₂ C(CH₃)₂, XC₆ H₄ CH₂ CH(CH₃), or XC₆ H₄ CH₂ C(CH₃)₂ (wherein X represents hydrogen, hydroxyl or methoxy); and Y represents hydrogen or hydroxy.

It is also described in the patent specification that these compounds exhibit a β-adrenergic blocking action.

British Pat. No. 902,617 discloses a series of compounds shown by the following general formula ##STR3## wherein R₁ is hydroxyl, methyl, methoxy, etc.; R₂ is hydrogen, methyl, etc.; R₃ is phenyl, benzyl or hydroxy-, methyl-, methoxy-, ethoxy-, chloro- or bromo-substituted phenyl or benzyl radical, etc.; and R₄ is hydrogen, etc.

These compounds exhibit an α-adrenergic blocking action (see, "J. Med. Chem.;" 9, 812-818(1966)) and possess an antihypertensive activity.

Also, in "J. Med. Chem.;" 9, 812-818(1966), there is decribed that the phenoxyethylamine-type compounds shown by the following general formula possess an α-adrenergic blocking action; ##STR4## wherein R₁ represents o-OCH₃, etc., and R₂ represents o-- or p--OCH₃, etc.

SUMMARY OF THE INVENTION

An object of this invention is to provide the novel sulfamoyl-substituted phenethylamine derivatives shown by following general formula and the acid addition salts thereof which possess a hypotensive activity based on an α-adrenergic blocking action and are useful as an antihypertensive agent, an agent for the treatment of congestive heart failure, etc.

Another object of this invention is to provide the process for producing the above-described pharmaceutically useful compounds.

That is, according to this invention, there are provided the sulfamoyl-substituted phenethylamine derivatives shown by following general formula I and the acid addition salts thereof ##STR5## wherein R₁ represents an amino group or a mono- or di-lower alkylamino group; R₂ represents a hydroxyl group, a lower alkyl group, or a lower alkoxy group; R₃ represents a hydrogen atom, halogen atom, a lower alkyl group, a lower alkoxy group, a phenylthio group, or a phenylsulfinyl group; R₄, R₅, R₆, R₇, R₈ and R₉ each represents a hydrogen atom or a lower alkyl group; R₁₀ represents a hydrogen atom, a lower alkyl group, or a lower alkoxy group; and Y represents an oxygen atom or a methylene group; said Y being, however, an oxygen atom when R₂ is a hydroxyl group.

DESCRIPTION OF THE PREFERRED EMBODIMENTS

Now, the term "lower" used in the above-described formula means a straight or branched carbon chain having 1 to 5 carbon atoms. Therefore, for example, a lower alkyl group includes a methyl group, ethyl group, propyl group, butyl group, pentyl group, isobutyl group, etc., and a lower alkoxy group includes a methoxy group, ethoxy group, propoxy group, butoxy group, etc. Also, in the above-described formula, R₁₀ which is a substituent of the benzene ring may be disposed at any position which is ortho, meta or para to the side chain. Furthermore, since the compounds of this invention shown by formula I can readily form the salts thereof and contain asymmetric carbon atom(s), the compounds of this invention include the salts thereof, the racemic compounds thereof, a mixture of the racemic compounds, and each optically active substance.

The compounds of formula I and the acid addition salts thereof provided by the present invention exhibit an α-adrenergic blocking action and thus they can be utilized for various treatments. For example, they can be used as useful agents for the treatments of hypertension, congestive heart failure, angina pectoris, lower urinary tract dysfunction, prostatic hypertrophy, pheochromocytoma and peripheral vascular disorders.

The compounds of this invention shown by formula I can be produced by the following processes.

Process 1:

The compounds of formula I are obtained by reacting the compounds shown by general formula II ##STR6## wherein R represents a hydrogen atom or a lower alkyl group and R₁, R₂, R₄, R₅, R₆, R₇, R₈, R₉, R₁₀ and Y have the same significance as in formula I

with a halogenating agent and then, if desired, (a) reducing the halogenated product obtained by the above reaction; or (b) reacting the halogenated product with an alkaline material and then reacting the product thus obtained with hydrogen iodide, a lower alcohol, or thiophenol, and further, if desired, oxidizing the product obtained by the reaction with thiophenol.

Process 1 is further described in more detail. That is, according to the process, the starting materials shown by formula II described above are reacted with a halogenating agent to provide the compounds shown by general formula I₁ ##STR7## wherein X represents a chlorine atom or bromine atom and R, R₁, R₂, R₄, R₅, R₆, R₇, R₈, R₉, R₁₀ and Y have the same significance as in formula II

and then, if desired, (a) the halogenated compounds shown by formula I₁ are reduced to form the compounds shown by formula I₂ ##STR8## wherein R, R₁, R₂, R₄, R₅, R₆, R₇, R₈, R₉, R₁₀ and Y have the same significance as above described;

or (b) the halogenated compounds shown by formula I₁ are treated with an alkaline material to form the aziridine compounds shown by the following general formula III ##STR9## wherein R₁, R₂, R₄, R₅, R₇, R₈, R₉, R₁₀ and Y have the same significance as above described,

then, the aziridine compounds are reacted with hydrogen iodide, a lower alcohol, or thiophenol to provide the compounds shown by general formula I₃ ##STR10## wherein R' represents an iodine atom, a lower alkoxy group or a phenylthio group and R₁, R₂, R₄, R₅, R₇, R₈, R₉, R₁₀ and Y have the same significance as above described and further, when R' of the compounds shown by formula I₃ is a phenylthio group, if desired, the compounds of I₃ are oxidized to provide the compounds shown by general formula I₄ ##STR11## wherein R₁, R₂, R₄, R₅, R₇, R₈, R₉, R₁₀ and Y have the same significance as above described.

This process is further schematically shown below, wherein the compounds shown by formulae I₁, I₂, I₃ and I₄ are the desired compounds of this invention. ##STR12##

The reaction condition in each step described above is as follows:

Step 1:

The halogenation of the compounds of formula II can be performed in an organic solvent such as toluene, methyl ethyl ketone, acetonitrile, tetrahydrofuran, etc., at room temperature or under heating using a halogenating agent such as thionyl chloride, hydrogen chloride, hydrogen bromide, phosphorus trichloride, phosphorus pentachloride, phosphorus oxychloride, thionyl bromide, etc.

Step 2:

The reduction of the compounds of formula I₁ can be performed in an organic solvent such as methanol, ethanol, toluene, acetonitrile, tetrahydrofuran, etc., under a hydrogen stream, at normal temperature and normal pressure using a catalyst such as platinum oxide, palladium carbon, etc.

Step 3:

The compounds of formula III can be obtained by treating the compounds of formula I₁ (wherein, however, R and R₆ are hydrogen atom) with an alkaline material such as sodium carbonate, metal alcoholate, sodium hydroxide, potassium hydroxide, etc., in an organic solvent such as ethyl acetate, ethanol, dioxane, benzene, etc., at room temperature to 50° C.

Step 4:

(i): The compounds of formula I₃ (wherein, R' is a phenylthio group) can be obtained by reacting the compounds of formula III with thiophenol in an organc solvent such as methanol, chloroform, ethyl acetate, dioxane, benzene, etc., at room temperature.

(ii): The compounds of formula I₃ (wherein, R' is a lower alkoxy group) can be obtained by reacting the compounds of formula III with a lower alcohol in the presence of a BF₃ catalyst under the same condition as in the step (i).

(iii): The compounds of formula I₃ (wherein, R' is an iodine atom) can be obtained by reacting the compounds of formula III with hydroiodic acid in an organic solvent such as dioxane, methanol, etc., at room temperature.

Step 5:

The oxidation of the compounds of formula I₃ (wherein R' is a phenylthio group) can be performed in acetic acid at a temperature of 50°-60° C. using H₂ O₂ as the oxidizing agent.

In addition, among the compounds of this invention, the compounds shown by following general formula I₅ ##STR13## wherein R" represents a lower alkoxy group or a phenylthio group and R, R₁, R₂, R₄, R₅, R₆, R₇, R₈, R₉, R₁₀ and Y have the same significance as above described can be obtained by reacting the compounds of formula I₁ directly with a lower alcohol or thiophenol.

The starting materials of formula II (wherein R is hydrogen atom) used in the process of this invention are described in British Pat. No. 2,006,772 and also the starting materials of formula II (wherein R is a lower alkyl group) can be obtained by reacting the compounds of the following formula ##STR14## described in the aforesaid British patent with a Grignard reagent (lower alkyl-MgX).

Process 2:

Among the compounds of formula I, the compounds of this invention shown by following general formula I₆ ##STR15## wherein R₁, R₂, R₃, R₄, R₇, R₈, R₉, R₁₀ and Y have the same significance as in formula I can be produced by condensing the compound shown by the general formula ##STR16## and the compound shown by the following formula ##STR17## and then reducing the products thus obtained.

This reaction is performed by condensing the compounds of formula IV and the compounds of formula V in an organic solvent such as methanol, ethanol, toluene, acetonitrile, tetrahydrofuran, etc., and then reducing the products in the presence of a PtO₂ catalyst or a Raney nickel catalyst or with NaBH₄, LiAlH₄, etc.

The isolation and purification of the compounds of this invention shown by general formulae I₁ -I₆ formed by Process 1 and 2 are performed by filtration, extraction with a solvent, separation by column chromatography, recrystallization, etc.

The pharmacological effects of the compounds of this invention were determined by the following experiments. The effects of the typical compounds of this invention were compared with 5-{1-hydroxy-2-[2-(2-methoxyphenoxy)ethylamino]ethyl}-2-methylbenzenesulfonamide (Compound A) which is one of the typical compounds disclosed in British Pat. No. 2,006,772 and phentolamine.

A. α-Adrenergic blocking action:

The blood pressure was measured in the rats anesthetized with urethane and treated with pentolinium. The effects of the test samples (intravenous injection) to antagonize the hypertensive response to phenylephrine (10 μg/Kg i.v.) were measured and the results were shown in Table I.

B. Antihypertensive effects in spontaneously hypertensive rats:

Oral administration: The systolic blood pressure was measured indirectly from the tail cuff method using a programmed electrosphygmanometer (Narco Bio-Systems Inc., PE-300) on spontaneously hypertensive rats having a systolic blood pressure higher than 150 mmHg, the results being shown in Table II.

                  TABLE I                                                          ______________________________________                                         α-Adrenergic blocking action:                                                           α-adrenergic blocking                                     Sample         ED.sub.50 (mg/Kg) i.v.                                          ______________________________________                                         Compounds of this                                                              invention (Ex. No.)                                                             4             0.00035                                                          5             0.00026                                                         10             0.0059                                                          11             0.012                                                           12             0.0073                                                          15             0.0013                                                          16             0.0008                                                          20             0.00000014                                                      25             0.0012                                                          26             0.004                                                           Known compounds                                                                Compound A     0.034                                                           Phentolamine   0.061                                                           ______________________________________                                    

                  TABLE II                                                         ______________________________________                                         Antihypertensive effect:                                                                               Change in systolic blood                                                       pressure (mmHg) at stated                              Sample      Dose (mg/Kg)                                                                               dose p.o.                                              ______________________________________                                         Compounds of this                                                              invention (Ex. No.)                                                            10          10          -57 ± 5.6                                           11          30          -50 ± 4.7                                           12          10          -48 ± 2.0                                           15          10          -54 ± 6.2                                           16          10          -71 ± 11.1                                          20           3          -57 ± 4.2                                           25          10          -46 ± 3.6                                           26          10          -46 ± 4.3                                           Known compounds                                                                Compound A  10          -35 ± 6.4                                           Phentolamine                                                                               10          +7.8 ± 5.0                                          "           100         -70 ± 10.1                                          ______________________________________                                    

The clinical administration of the compounds of this invention is usually practiced by intravenous injection or orally as the free bases or the acid addition salts thereof (e.g., hydrochlorides, sulfates, maleates, acetates, furarates, lactates, citrates, etc.). It is proper to administer 10 ng-1 mg per ounce of the compound several times per day in case of intravenous administration or 0.1-100 mg of the compound two or three times per day in the case of oral administration.

The compounds of this invention may be formulated into ordinary dosage forms such as, for example, tablets, capsules, pills, solutions, etc., and in these cases, the medicaments can be prepared by conventional methods with conventional pharmaceutical excipients.

Then, the production of the compounds of this invention will be further described in the following examples. In addition, the starting materials used in this invention include novel compounds and the production thereof are shown in the Reference Examples.

Reference Example 1 ##STR18##

(1) To 250 g of chlorosulfonic acid was added dropwise 50 g of 4-methoxyphenylacetone at 0°-5° C. After stirring the mixture for 4 hours at room temperature, the reaction mixture was poured into 2,500 ml of ice water and extracted three times with 500 ml of ethyl acetate. The extract was washed with water and after drying the extract with anhydrous magnesium sulfate, the solvent was distilled off under reduced pressure. The crude crystals obtained were recrystallized from benzene-ether to provide 32 g of 3-chlorosulfonyl-4-methoxyphenylacetone.

Melting point: 80°-81° C.

(2) In 26 ml of tetrahydrofuran was dissolved 2.6 g of 3-chlorosulfonyl-4-methoxyphenylacetone and then 1.2 g of 40% methylamine was added dropwise to the solution at a temperature lower than 10° C. After stirring the mixture for one hour at room temperature, the solvent was distilled off under reduced pressure and the residue was extracted with ethyl acetate. The extract was washed with water and after drying with anhydrous magnesium sulfate, the solvent was distilled off under reduced pressure. The crude crystals obtained were recrystallized from isopropanol-ether to provide 1.8 g of 4-methoxy-3-N-methylsulfamylphenylacetone.

Melting point: 100°-101° C.

Reference Example 2. ##STR19##

By reacting 2.6 g of 3-chlorosulfonyl-4-methoxyphenylacetone and 0.6 g of dimethylamine in the same manner as in Reference Example 1-(2), 2.5 g of oily 4-methoxy-3-N,N-dimethylsulfamylphenylacetone was obtained.

Nuclear magnetic resonance spectra (CDCl₃):

    ______________________________________                                                δ:                                                                           2.18 (3H, S, COCH.sub.3)                                                       2.82 (6H, S, N(CH.sub.3).sub.2)                                                 ##STR20##                                                                     3.90 (3H, S, OCH.sub.3)                                             ______________________________________                                    

EXAMPLE 1 ##STR21##

In 1,000 ml of acetonitrile was suspended 17 g of 5-{2-[2-(2-ethoxyphenoxy)ethylamino]-1-hydroxy-2-methyl-ethyl}-2-methoxybenzenesulfonamide hydrochloride and while stirring the suspension, 9 g of thionyl chloride was added dropwise to the suspension at room temperature, whereby the product was dissolved and then began crystallize gradually. After stirring the mixture for two days, the crystals formed were recovered by filtration, washed with chloroform and dried to provide 15 g of 5-{1-chloro-2-[2-(2-ethoxyphenoxy)ethylamino]-2-methylethyl}-2-methoxybenzenesulfonamide hydrochloride.

The product has the following physicochemical properties.

Melting point: 197°-200° C.

Elemental analysis for C₂₀ H₂₇ N₂ O₅ SCl.HCl:

    ______________________________________                                                C(%)        H(%)    N(%)                                                ______________________________________                                         Calcd.:  50.11         5.89    5.84                                            Found:   50.06         5.96    5.95                                            ______________________________________                                    

Nuclear magnetic resonance spectra (CD₃ OD):

    ______________________________________                                         δ:                                                                              1.30          (3H, d, CH--CH.sub.3)                                            1.40          (3H, t, CH.sub.2 --CH.sub.3)                                     3.63          (2H, t, CH.sub.2 --CH.sub.2 --N)                                 4.01          (3H, s, O--CH.sub.3)                                             4.12          (2H, q, CH.sub.3 --CH.sub.2 --O)                                 4.36          (2H, t, CH.sub.2 --CH.sub.2 --O)                                 5.30          (1H, d, Cl--CH)                                           ______________________________________                                    

The compounds in Examples 2 and 3 were obtained in the same manner as in Example 1.

EXAMPLE 2 ##STR22##

5-{1-Chloro-2-[2-(2-methoxyphenoxy)ethylamino]ethyl}-2-methylbenzenesulfonamide hydrochloride

Physicochemical properties:

Melting point: 190°-191° C.

Elemental analysis for C₁₈ H₂₃ N₂ O₄ SCl.HCl:

    ______________________________________                                                  C(%)       H(%)    N(%)                                               ______________________________________                                         Calculated:                                                                               49.66        5.56    6.43                                           Found:     49.51        5.70    6.53                                           ______________________________________                                    

Nuclear magnetic resonance spectra (d₆ -DMSO):

    ______________________________________                                         δ:                                                                              ##STR23##                                                                      ##STR24##                                                               ______________________________________                                    

EXAMPLE 3 ##STR25##

5-{1-Chloro-2-[2-(2-methoxyphenoxy)ethylamino]-2-methylethyl}-2-methoxybenzenesulfonamide hydrochloride

Physicochemical properties:

Melting point: 195°-197° C. (decomposed)

Elemental analysis for C₁₉ H₂₅ N₂ O₅ SCl.HCl:

    ______________________________________                                                  C(%)       H(%)    N(%)                                               ______________________________________                                         Calculated:                                                                               49.04        5.63    6.02                                           Found:     49.02        5.64    6.08                                           ______________________________________                                    

Nuclear magnetic resonance spectra (CD₃ OD+d₆ -DMSO)

    ______________________________________                                         δ:                                                                                 ##STR26##                                                                     3.80 and 3.95 (3H + 3H, s, OCH.sub.3)                                           ##STR27##                                                            ______________________________________                                    

EXAMPLE 4 ##STR28##

A mixture of 1.4 g of 4-methoxy-3-N-methylsulfamylphenylacetone, 1 g of 2-methoxyphenoxyethylamine, and 30 ml of methanol was refluxed for one hour. After cooling the mixture, 60 mg of a platinum oxide catalyst was added thereto, the reduction was performed at normal temperature and pressure. After absorbing a theoretical amount of hydrogen, the catalyst was filtered away. After the filtrate was acidified with an alcoholic 5% hydrochloric acid, the solvent was distilled off under reduced pressure to form 1.6 g of crystals, which were recovered and recrystallized to provide 1.2 g of the colorless crystals of 2-methoxy-5-{2-[2-(2-methoxyphenoxy)ethylamino]-2-methylethyl}-N-methylbenzenesulfonamide hydrochloride.

The product has the following physicochemical properties.

Melting point: 162°-163° C.

Elemental analysis for C₂₀ H₂₈ N₂ O₅ S.HCl:

    ______________________________________                                                C(%)        H(%)    N(%)                                                ______________________________________                                         Calcd.:  53.99         6.57    6.30                                            Found:   53.85         6.70    6.27                                            ______________________________________                                    

Nuclear magnetic resonance spectra (d₆ -DMSO)

    ______________________________________                                         δ:   1.15 (3H, d, --CHCH.sub.3)                                                     3.76 and 3.88 (3H + 3H, S, O--CH.sub.3)                             ______________________________________                                    

The product of Example 5 was obtained in the same manner as in Example 4.

EXAMPLE 5 ##STR29##

2-Methoxy-5-{2-[2-(2-methoxyphenoxy)ethylamino]-2-methylethyl}-N,N-dimethylbenzenesulfonamide hydrochloride

Physicochemical properties:

Melting point: 185°-187° C.

Elemental analysis for C₂₁ H₃₀ N₂ O₅ S.HCl

    ______________________________________                                                  C(%)       H(%)    N(%)                                               ______________________________________                                         Calculated:                                                                               54.95        6.81    6.10                                           Found:     54.73        6.88    5.85                                           ______________________________________                                    

Nuclear magnetic resonance spectra (d₆ -DMSO)

    ______________________________________                                         δ: 1.16 (3H, d, CHCH.sub.3), 2.71 (6H, s, N(CH.sub.3).sub.2)               3.76 and 3.87 (3H + 3H, s, --O--CH.sub.3)                                    ______________________________________                                    

REFERENCE EXAMPLE 3 ##STR30##

In 50 ml of ethyl acetate was suspended 4.35 g (0.01 mole) of 5-{1-chloro-2-[2-(2-methoxyphenoxy)ethylamino]ethyl}-2-methylbenzenesulfonamide hydrochloride and then 50 ml of an aqueous 10% sodium carbonate solution was added to the suspension with stirring. After further stirring overnight vigorously, the reaction mixture was recovered by decantation. After removing inorganic matters by passing the ethyl acetate layer thus recovered through a silica gel column (50 ml of silica gel), the reaction product was evaporated to dryness to provide 3.2 g (88%) of colorless resinous 5-{1-[2-(2-methoxyphenoxy)-ethyl]aziridin-2-yl}-2-methylbenzenesulfonamide

The product has the following physicochemical properties. Amorphous form.

Elemental analysis for C₁₈ H₂₂ N₂ O₄ S:

    ______________________________________                                                C (%)       H (%)   N (%)                                               ______________________________________                                         Calcd.:  59.65         6.12    7.73                                            Found:   59.37         6.12    7.61                                            ______________________________________                                    

Nuclear magnetic resonance spectra (CDCl₃):

    ______________________________________                                          δ:                                                                             1.74 and 1.95                                                                              (1H + 1H,                                                                                d,                                                                                 ##STR31##                                            2.43        (1H,      q,                                                                                 ##STR32##                                            2.55        (3H,      s                                                                                  ##STR33##                                           4.10        (2H,      t,  OCH.sub.2)                                     ______________________________________                                    

EXAMPLE 6 ##STR34##

In 50 ml of dioxane was dissolved 2.5 g of 5-{1-[2-(2-methoxyphenoxy)ethyl]aziridin-2-yl}-2-methylbenzenesulfonamide and after adding thereto 1 g of concentrated hydroiodic acid, the mixture was stirred overnight. After the reaction was over, the solvent was distilled off under reduced pressure and the residue was washed three times with 30 ml of water and then three times with 200 ml of ether and crystallized by the addition of ethyl acetate. The crystals were recovered by filtration, washed with water, and dried to provide 1.7 g of 5-{1-iodo-2-[2-(2-methoxyphenoxyethylamino]ethyl}-2-methylbenzenesulfonamide hydroiodide.

The product has the following physicochemical properties.

Melting point: 154°-155° C.

Elemental analysis for C₁₈ H₂₃ N₂ O₄ SI.HI:

    ______________________________________                                                C (%)       H (%)   N (%)                                               ______________________________________                                         Calcd.:  34.97         3.91    4.53                                            Found:   35.07         3.98    4.39                                            ______________________________________                                    

Nuclear magnetic resonance spectra (CD₃ OD):

    ______________________________________                                          δ:                                                                              2.65         (3H,   s,                                                                                 ##STR35##                                             3.54         (2H,   t,  CH.sub.2N)                                             4.30         (2H,   t,  CH.sub.2O)                                              5.55         (1H,   t,                                                                                 ##STR36##                                      ______________________________________                                    

EXAMPLE 7 ##STR37##

In 50 ml of methanol was dissolved 2.5 g of 5-{1-[2-(2-methoxyphenoxy)ethyl]aziridin-2-yl}-2-methylbenzenesulfonamide and after adding 1 g of thiophenol to the solution and stirring overnight the mixture at room temperature, methanol was distilled off. The residue was applied to a silica gel column chromatography and the product was eluted with a mixed solvent of chloroform and methanol (9:1 by volume ratio) to provide 2.4 g of 5-{2-[2-(2-methoxyphenoxy)-ethylamino]-1-phenylthioethyl}-2-methylbenzenesulfonamide as a viscous oily material.

The product has the following physicochemical properties.

Amorphous form.

Elemental analysis for C₂₄ H₂₈ N₂ O₄ S₂ :

    ______________________________________                                                C (%)       H (%)   N (%)                                               ______________________________________                                         Calcd.:  60.99         5.97    5.93                                            Found:   60.72         6.11    5.71                                            ______________________________________                                    

Nuclear magnetic resonance spectra (CDCl₃):

    ______________________________________                                          δ:                                                                              2.58          (3H,   s,                                                                                 ##STR38##                                            3.74          (3H,   s,  OCH.sub.3)                                            3.98          (2H,   t,  CH.sub.2O)                                             4.35          (1H,   t,                                                                                 ##STR39##                                     ______________________________________                                    

EXAMPLE 8 ##STR40##

In 50 ml of methanol was dissolved 2.5 g of 5-{1-[2-(2-methoxyphenoxy)ethyl]aziridin-2-yl}-2-methylbenzenesulfonamide and after adding thereto 2 ml of a boron trifluoride ether complex at room temperature, the mixture was stirred overnight. Thereafter, methanol was distilled off under reduced pressure and the residue was applied to a silica gel column chromatography. The product was then eluted with a mixed solvent of chloroform and methanol (9:1 by volume ratio), whereby 1.5 g of a colorless viscous oily material was obtained. The product was crystallized by the addition of 5 ml of methanol and several drops of ammonia. The crystals formed were recovered by filtration, washed with water, and dried to provide 1.2 g of 5-{1-methoxy-2-[2-(2-methoxyphenoxy)ethylamino]ethyl}-2-methylbenzenesulfonamide.

The product has the following physicochemical properties.

Melting point: 150°-152° C.

Elemental analysis for C₁₉ H₂₆ N₂ O₅ S:

    ______________________________________                                                C (%)       H (%)   N (%)                                               ______________________________________                                         Calcd.:  57.85         6.64    7.10                                            Found:   57.58         6.79    7.24                                            ______________________________________                                    

Nuclear magnetic resonance spectra (CD₃ OD):

    ______________________________________                                          δ:                                                                              2.65         (3H,   s,                                                                                 ##STR41##                                             2.98         (2H,   t,  CH.sub.2 N)                                             3.80         (3H,   s,                                                                                 ##STR42##                                             3.26         (3H,   s,  CHOCH.sub.3)                                           4.10         (2H,   t,  CH.sub.2 O)                                             4.40         (1H,   q,                                                                                 ##STR43##                                      ______________________________________                                    

EXAMPLE 9 ##STR44##

In 20 ml of acetic acid was dissolved 2 g of 5-{2-[2-(2-methoxyphenoxy)ethylamino]-1-phenylthioethyl}-2-methylbenzenesulfonamide and after adding thereto 0.5 ml of 30% H₂ O₂, the mixture was heated to 50°-60° C. for 3 hours. After adding thereto 100 ml of water, the reaction mixture was extracted with 200 ml of ethyl acetate. The ethyl acetate extract was washed with an aqueous 1% sodium carbonate solution and then ethyl acetate was distilled off under reduced pressure. The residue was applied to a silica gel column chromatography, the product was eluted with a mixed solvent of chloroform and methanol (9:1 by volume ratio), and the colorless viscous oily product thus obtained was crystallized by the addition of ethyl acetate. The crystals formed were recovered by filtration to provide 1.3 g of 5-{2-[2-(2-methoxyphenoxy)-ethylamino]-1-phenylsulfinylethyl}-2-methylbenzenesulfonamide.

The product has the following physicochemical properties.

Melting point: 139°-141° C.

Elemental analysis for C₂₄ H₂₈ N₂ O₅ S₂ :

    ______________________________________                                                C(%)        H(%)    N(%)                                                ______________________________________                                         Calcd.:  59.00         5.78    5.73                                            Found:   58.91         5.74    5.72                                            ______________________________________                                    

EXAMPLE 10 ##STR45##

In 150 ml of methanol was dissolved 3.8 g of 5-{1-chloro-2-[2-(2-methoxyphenoxy)ethylamino]ethyl}-2-methoxybenzenesulfonamide hydrochloride and after adding thereto 0.5 g of 10% palladium carbon, it was dechlorinated under a hydrogen stream at normal temperature and pressure. Then, palladium carbon was filtered away and the filtrate was concentrated under reduced pressure to provide 3.1 g of 2-methoxy-5-{2-[2-(2-methoxyphenoxy)ethylamino]ethyl}benzenesulfonamide hydrochloride, which was recrystallized from 120 ml of a mixture of methanol and ethanol (1:4 by volume ratio) to provide 2.3 g of the colorless crystals thereof.

The product has the following physiocochemical properties.

Melting point: 196°-198° C.

Elemental analysis for C₁₈ H₂₄ N₂ O₅ S.HCl):

    ______________________________________                                                C(%)        H(%)    N(%)                                                ______________________________________                                         Calcd.:  51.86         6.04    6.72                                            Found:   51.72         6.23    6.68                                            ______________________________________                                    

Nuclear magnetic resonance spectra (CD₃ OD):

    ______________________________________                                         δ: 3.84 and 3.98                                                                               (3H + 3H, s, --OCH.sub.3)                                         4.24         (2H, t, --OCH.sub.2 --)                                  ______________________________________                                    

The compounds in Examples 11-29 were obtained in the same manner as in Example 10.

EXAMPLE 11 ##STR46##

5-{2-[2-(2-Methoxyphenoxy)ethylamino]ethyl}-2-methylbenzenesulfonamide hydrochloride

Physicochemical properties

Melting point: 173°-175° C.

Elemental analysis for C₁₈ H₂₄ N₂ O₄ S.HCl:

    ______________________________________                                                 C (%)       H (%)   N (%)                                              ______________________________________                                         Calculated:                                                                              53.93         6.28    6.99                                           Found:    53.83         6.27    6.97                                           ______________________________________                                    

Nuclear magnetic resonance spectra (CD₃ OD)

    ______________________________________                                          δ:                                                                             ##STR47##          3.84 (3H, s, OCH.sub.3)                                    4.28 (2H, t, OCH.sub.2)                                                  ______________________________________                                    

EXAMPLE 12 ##STR48##

5-{2-[2-(2-Ethoxyphenoxy)ethylamino]ethyl}-2-methylbenzenesulfonamide hydrochloride

Physicochemical properties

Melting point: 180°-181.5° C.

Elemental analysis for C₁₉ H₂₆ N₂ O₄ S.HCl

    ______________________________________                                                 C (%)       H (%)   N (%)                                              ______________________________________                                         Calculated:                                                                              55.00         6.56    6.75                                           Found:    54.81         6.56    6.89                                           ______________________________________                                    

Nuclear magnetic resonance spectra (CD₃ OD):

    ______________________________________                                          δ:                                                                           1.36 (3H, t, OCH.sub.2 CH.sub.3),                                                                ##STR49##                                                   4.10 (2H, q, OCH.sub.2 CH.sub.3),                                                                4.36 (2H, t, OCH.sub.2CH.sub.2)                          ______________________________________                                    

EXAMPLE 13 ##STR50##

5-{2-[2-(2-Methoxyphenoxy)-1-methylethylamino]ethyl}-2-methylbezenesulfonamide hydrochloride

Physicochemical properties:

Melting point: 169°-171° C.

Elemental analysis for C₁₉ H₂₆ N₂ O₄ S.HCl

    ______________________________________                                                 C (%)       H (%)   N (%)                                              ______________________________________                                         Calculated:                                                                              55.00         6.56    6.75                                           Found:    54.89         6.60    6.76                                           ______________________________________                                    

Nuclear magnetic resonance spectra (CD₃ OD):

    ______________________________________                                          δ:                                                                           ##STR51##                                                                                        ##STR52##                                                   3.80 (3H, s, OCH.sub.3)                                                    ______________________________________                                    

EXAMPLE 14 ##STR53##

5-{2-[3-(2-Methoxyphenyl)-1-methylpropylamino]ethyl}-2-methylbenzenesulfonamide hydrochloride

Physicochemical properties:

Melting point: 198°-200° C.

Elemental analysis for C₂₀ H₂₈ N₂ O₃ S.HCl

    ______________________________________                                                 C (%)       H (%)   N (%)                                              ______________________________________                                         Calculated:                                                                              58.17         7.08    6.78                                           Found:    58.09         7.01    6.62                                           ______________________________________                                    

Nuclear magnetic resonance spectra (d₆ -DMSO)

    ______________________________________                                          δ:                                                                           ##STR54##                                                                                        ##STR55##                                                   3.78 (3H, s, OCH.sub.3)                                                    ______________________________________                                    

EXAMPLE 15 ##STR56##

2-Hydroxy-5-{2-[2-(2-methoxyphenoxy)ethylamino]ethyl}benzenesulfonamide

Physicochemical properties:

Melting point: 97°-99° C.

Elemental analysis for C₁₇ H₂₂ N₂ O₅ S.H₂ O

    ______________________________________                                                 C (%)       H (%)   N (%)                                              ______________________________________                                         Calculated:                                                                              53.10         6.29    7.29                                           Found:    52.75         6.22    7.09                                           ______________________________________                                    

Nuclear magnetic resonance spectra (d₆ -DMSO)

    ______________________________________                                         δ: 3.76           (3H, s, --OCH.sub.3)                                            4.04           (2H, t, --OCH.sub.2 --)                                ______________________________________                                    

EXAMPLE 16 ##STR57##

2-Methoxy-5-{2-[2-(2-methoxyphenoxy)ethylamino]-2-methylethyl}benzenesulfonamide hydrochloride

Physicochemical properties:

Melting point: above 250° C.

Elemental analysis for C₁₉ H₂₆ N₂ O₅ S.HCl

    ______________________________________                                                 C (%)       H (%)   N (%)                                              ______________________________________                                         Calculated:                                                                              52.96         6.31    6.50                                           Found:    52.44         6.31    6.47                                           ______________________________________                                    

Nuclear magnetic resonance spectra (d₆ -DMSO) ##STR58##

EXAMPLE 17 ##STR59##

2-Methyl-5-{2-[2-(2-methylphenoxy)-1-methylethylamino]ethyl}benzenesulfonamide hydrochloride

Physicochemical properties:

Melting point: 183°-185° C.

Elemental analysis for C₁₉ H₂₆ N₂ O₃ S.HCl:

    ______________________________________                                                 C (%)       H (%)   N (%)                                              ______________________________________                                         Calculated:                                                                              57.20         6.82    7.02                                           Found:    52.13         6.79    6.99                                           ______________________________________                                    

Nuclear magnetic resonance spectra (CD₃ OD) ##STR60##

EXAMPLE 18 ##STR61##

2-Methyl-5-[2-(2-phenoxyethylamino)ethyl]benzenesulfonamide hydrochloride

Physicochemical properties:

Melting point: 208.5°-210° C.

Elemental analysis for C₁₇ H₂₂ N₂ O₃ S.HCl:

    ______________________________________                                                 C (%)       H (%)   N (%)                                              ______________________________________                                         Calculated:                                                                              55.05         6.25    7.55                                           Found:    54.83         6.23    7.48                                           ______________________________________                                    

Nuclear magnetic resonance spectra (CD₃ OD) ##STR62##

EXAMPLE 19 ##STR63##

5-{2-[2-(2-Methoxyphenoxy)ethylamino]-2,2-dimethylethyl}-2-methylbenzenesulfonamide hydrochloride

Physicochemical properties:

Melting point: 199°-202° C.

Elemental analysis for C₂₀ H₂₈ N₂ O₄ S.HCl.CH₃ OH

    ______________________________________                                                 C (%)       H (%)   N (%)                                              ______________________________________                                         Calculated:                                                                              54.71         7.21    6.08                                           Found:    54.50         7.17    6.14                                           ______________________________________                                    

Nuclear magnetic resonance spectra (d₆ -DMSO) ##STR64##

EXAMPLE 20 ##STR65##

5-{2-[2-(2-Ethoxyphenoxy)ethylamino]-2-methylethyl}-2-methoxybenzenesulfonamide hydrochloride

Physicochemical properties:

Melting point: 254°-256° C.

Elemental analysis for C₂₀ H₂₈ N₂ O₅ S.HCl

    ______________________________________                                                 C (%)       H (%)   N (%)                                              ______________________________________                                         Calculated:                                                                              53.99         6.57    6.30                                           Found:    53.79         6.58    6.26                                           ______________________________________                                    

Nuclear magnetic resonance spectra (CD₃ OD): ##STR66##

EXAMPLE 21 ##STR67##

5-{2-[2-(2-Methoxyphenoxy)ethylamino]-1-methylethyl}-2-methylbenzenesulfonamide hydrochloride

Physicochemical properties:

Melting point: 183°-185° C.

Elemental analysis for C₁₉ H₂₆ N₂ O₄ S.HCl:

    ______________________________________                                                 C (%)       H (%)   N (%)                                              ______________________________________                                         Calculated:                                                                              55.00         6.56    6.75                                           Found:    54.76         6.56    6.74                                           ______________________________________                                    

Nuclear magnetic resonance spectra (CD₃ OD) ##STR68##

EXAMPLE 22 ##STR69##

5-{2-[2-(2-Methoxyphenoxy)-2-methylethylamino]ethyl}-2-methylbezenesulfonamide hydrochloride

Physicochemical properties:

Melting point: 231°-232° C.

Elemental analysis for C₁₉ H₂₆ N₂ O₄ S.HCl:

    ______________________________________                                                 C (%)       H (%)   N (%)                                              ______________________________________                                         Calculated:                                                                              55.00         6.56    6.75                                           Found:    54.86         6.58    6.83                                           ______________________________________                                    

Nuclear magnetic resonance spectra (CD₃ OD): ##STR70##

EXAMPLE 23 ##STR71##

5-{2-[2-(2-Methoxyphenoxy)-1,1-dimethylethylamino]ethyl}-2-methylbenzenesulfonamide hydrochloride

Physicochemical properties:

Melting point: 191°-193° C.

Elemental analysis for C₂₀ H₂₈ N₂ O₄ S.HCl:

    ______________________________________                                                 C (%)       H (%)   N (%)                                              ______________________________________                                         Calculated:                                                                              56.00         6.81    6.53                                           Found:    55.83         6.86    6.32                                           ______________________________________                                    

Nuclear magnetic resonance spectra (d₆ -DMSO): ##STR72##

EXAMPLE 24 ##STR73##

5-{2-[N-[2-(2-Methoxyphenoxy)ethyl]-N-methylamino]ethyl}-2-methylbenzenesulfonamide hydrochloride

Physicochemical properties:

Melting point: 169°-171° C.

Elemental analysis for C₁₉ H₂₆ N₂ O₄ S.HCl:

    ______________________________________                                                 C (%)       H (%)   N (%)                                              ______________________________________                                         Calculated:                                                                              55.00         6.56    6.75                                           Found:    54.88         6.51    6.64                                           ______________________________________                                    

Nuclear magnetic resonance spectra (d₆ -DMSD): ##STR74##

EXAMPLE 25 ##STR75##

5-{2-[2-(2-Methoxyphenoxy)ethylamino]-2-methylethyl}-2-methylbenzenesulfonamide hydrochloride

Physicochemical properties:

Melting point: 250°-252° C.

Elemental analysis for C₁₉ H₂₆ N₂ O₄ S.HCl:

    ______________________________________                                                 C (%)       H (%)   N (%)                                              ______________________________________                                         Calculated:                                                                              55.00         6.56    6.75                                           Found:    54.68         6.49    6.58                                           ______________________________________                                    

Nuclear magnetic resonance spectra (CDCl₃ +d₆ -DMSO+D₂ O+Na₂ CO₃): ##STR76##

EXAMPLE 26 ##STR77##

5-{2-[2-(2-Methoxyphenoxy)ethylamino]-2-ethylethyl}-2-methylbenzenesulfonamide hydrochloride

Physicochemical properties:

Melting point: 198°-200° C.

Elemental analysis for C₂₀ H₂₈ N₂ O₄ S.HCl

    ______________________________________                                                 C (%)       H (%)   N (%)                                              ______________________________________                                         Calculated:                                                                              56.00         6.81    6.53                                           Found:    55.76         6.88    6.51                                           ______________________________________                                    

Nuclear magnetic resonance spectra (CDCl₃ +d₆ -DMSO+D₂ O+Na₂ CO₃): ##STR78##

EXAMPLE 27 ##STR79##

2-Hydroxy-5-{2-[2-(4-methoxyphenoxy)ethylamino]ethyl}-benzenesulfonamide hydrochloride

Physicochemical properties:

Melting point: 237°-241° C. (decomposed):

Elemental analysis for C₁₇ H₂₂ N₂ O₅ S.HCl:

    ______________________________________                                                  C (%)      H (%)   N (%)                                              ______________________________________                                         Calculated:                                                                               50.68        5.75    6.95                                           Found:     50.45        5.64    6.99                                           ______________________________________                                    

Nuclear magnetic resonance spectra (CD₃ OD): ##STR80##

Example 28 ##STR81##

2-Hydroxy-5-{2-[2-(2-methoxyphenoxy)ethylamino]-2-methylethyl}benzenesulfonamide hydrochloride

Physicochemical properties:

Melting point: 211°-214° C.

Elemental analysis for C₁₈ H₂₄ N₂ O₅ S.HCl:

    ______________________________________                                                  C (%)      H (%)   N (%)                                              ______________________________________                                         Calculated:                                                                               51.86        6.04    6.72                                           Found:     51.72        6.00    6.59                                           ______________________________________                                    

Nuclear magnetic resonance (CD₃ OD): ##STR82##

EXAMPLE 29 ##STR83##

5-{2-[2-(2-Ethoxyphenoxy)ethylamino]-2-methylethyl}-2-hydroxybenzenesulfonamide hydrochloride

Physicochemical properties:

Melting point: 172°-173° C.

Elemental analysis for C₁₉ H₂₆ N₂ O₅ S.HCl:

    ______________________________________                                                  C (%)      H (%)   N (%)                                              ______________________________________                                         Calculated:                                                                               52.96        6.31    6.50                                           Found:     52.83        6.65    6.12                                           ______________________________________                                    

Nuclear magnetic resonance spectra (CD₃ OD): ##STR84##

The starting materials and the reaction types applied to prepare the products of the above Examples 2,3,5 and 11-29 are shown below schematically;

    ______________________________________                                         Example                                                                        No.    Starting Material & Reaction Type                                       ______________________________________                                                 ##STR85##                                                              3                                                                                      ##STR86##                                                              5                                                                                      ##STR87##                                                              11-29                                                                                  ##STR88##                                                                     (X represents halogen;                                                         R, R.sub.1, R.sub.2 and R.sub.4 -R.sub.10 in                                   the formula represent                                                          the same group as the                                                          corresponding group of                                                         the desired product)                                                    ______________________________________                                     

What is claimed is:
 1. A process for producing sulfamoyl-substituted phenethylamine derivatives represented by the formula ##STR89## wherein R₁ represents an amino group or a mono- or di-lower alkylamino group; R₂ represents a hydroxyl group, a lower alkyl group, or a lower alkoxy group; R₃ represents a hydrogen atom, a halogen atom, a lower alkyl group, a lower alkoxy group, a phenylthio group, or a phenylsulfinyl group; R₄, R₇, R₈ and R₉ each represent a hydrogen atom or a lower alkyl group; R₁₀ represents a hydrogen atom, a lower alkyl group, or a lower alkoxy group and Y represents an oxygen atom or a methylene group; said Y is an oxygen atom when R₂ is a hydroxyl group or the salts thereof which comprises condensing a compound represented by the formula ##STR90## wherein R₁, R₂, R₃ and R₄ have the same significance as in the above formulaand a compound represented by the formula ##STR91## wherein R₇, R₈, R₉, R₁₀ and Y have the same significance as in the above formula and then reducing the condensation product.
 2. A process for producing sulfamoyl-substituted phenethylamine derivatives represented by the formula ##STR92## wherein R₁ represents an amino group or a mono- or di-lower alkylamino group; R₂ represents a hydroxyl group, a lower alkyl group or a lower alkoxy group; R₃ represents a chlorine or bromine atom; R₄, R₅, R₆, R₇, R₈ and R₉ each represent a hydrogen atom or a lower alkyl group; R₁₀ represents a hydrogen atom, a lower alkyl group, or a lower alkoxy group; and Y represents an oxygen atom or a methylene group; said Y being an oxygen atom when R₂ is a hydroxyl group, or the salts thereof which comprises reacting a compound represented by the formula ##STR93## wherein R represents a hydrogen atom or a lower alkyl group and R₁, R₂, R₄, R₅, R₆, R₇, R₈, R₉, R₁₀ and Y have the same significance as in the above formula with a chlorinating or brominating agent.
 3. A process for producing sulfamoyl-substituted phenethylamine derivatives represented by the formula ##STR94## wherein R₁ represents an amino group or a mono- or di-lower alkylamino group; R₂ represents a hydroxy group, a lower alkyl group or a lower alkoxy group; R₃ represents a hydrogen atom or a lower alkyl group; R₄, R₅, R₆, R₇, R₈ and R₉ each represent a hydrogen atom or a lower alkyl group; R₁₀ represents a hydrogen atom, a lower alkyl group, or a lower alkoxy group; and Y represents an oxygen atom or a methylene group; said Y being an oxygen atom when R₂ is a hydroxyl group, or the salts thereof which comprises reacting a compound represented by the formula ##STR95## wherein R represents a hydrogen atom or a lower alkyl group and R₁, R₂, R₄, R₅, R₆, R₇, R₈, R₉, R₁₀ and Y have the same significance as in the above formula with a halogenating agent and reducing the halogenated product.
 4. The process as defined in claim 3 for the preparation of 5-[2-[2-(2-ethoxyphenoxy)ethylamino]-2-methylethyl]-2-methoxybenzenesulfonamide.
 5. The process as defined in claim 3 for the preparation of 2-methoxy-5-[2-[2-(2-methoxyphenoxy)ethylamino]-2-methylethyl]-benzensulfonamide.
 6. The process as defined in claim 3 for the preparation of 5-[2-[2-(2-methoxyphenoxy)ethylamino]-2-methylethyl]-2-methylbenzenesulfonamide.
 7. The process as defined in claim 3 for the preparation of 5-[2-[2-(2-methoxyphenoxy)ethylamino]ethyl]-2-methylbenzenesulfonamide.
 8. The process as defined in claim 3 for the preparation of 2-methoxy-5-[2-[2-(2-methoxyphenoxy)ethylamino]-2-methylethyl]-N-methylbenzenesulfonamide.
 9. The process as defined in claim 3 for the preparation of 2-methoxy-5-[2-[2-(2-methoxyphenoxy)ethylamino]-2-methylethyl]-N,N-dimethylbenzenesulfonamide.
 10. The process for producing sulfamoyl-substituted phenethylamine derivatives represented by the formula ##STR96## wherein R₁ represents an amino group or a mono- or di-lower alkylamino group; R₂ represents a hydroxyl group, a lower alkyl group or a lower alkoxy group; R₃ represents phenylsulfinyl; R₄, R₅, R₆, R₇, R₈ and R₉ each represent a hydrogen atom or a lower alkyl group; R₁₀ represents a hydrogen atom, a lower alkyl group, or a lower alkoxy group; and Y represents an oxygen atom or a methylene group; said Y being an oxygen atom when R₂ is a hydroxyl group, or the salts thereof which comprises reacting a compound represented by the formula ##STR97## wherein R represents a hydrogen atom or a lower alkyl group and R₁, R₂, R₄, R₅, R₆, R₇, R₈, R₉, R₁₀ and Y have the same significance as in the above formula with a halogenating agent to form a halogenated product, reacting said halogenated product with an alkaline material, reacting the product thus obtained with thiophenol, and oxidizing the resulting product.
 11. A process for producing sulfamoyl-substituted phenethylamine derivatives represented by the formula ##STR98## wherein R₁ represents an amino group or a mono- or di-lower alkylamino group; R₂ represents a hydroxyl group, a lower alkyl group or a lower alkoxy group; R₃ represents iodine; R₄, R₅, R₆, R₇, R₈ and R₉ each represent a hydrogen atom or a lower alkyl group; R₁₀ represents a hydrogen atom, a lower alkyl group, or a lower alkoxy group; and Y represents an oxygen atom or a methylene group; said Y being an oxygen atom when R₂ is a hydroxyl group, or the salts thereof which comprises reacting a compound represented by the formula ##STR99## wherein R represents a hydrogen atom or a lower alkyl group and R₁, R₂, R₄, R₅, R₆, R₇, R₈, R₉, R₁₀ and Y have the same significance as in the above formula with a halogenating agent to form a halogenated product ##STR100## wherein X represents a chlorine atom or bromine atom and R and R₆ are hydrogen, reacting said halogenated product with an alkaline material and then reacting the product ##STR101## thus obtained with hydrogen iodide.
 12. A process for producing sulfamoyl-substituted phenethylamine derivatives represented by the formula ##STR102## wherein R₁ represents an amino group or a mono- or di-lower alkylamino group; R₂ represents a hydroxyl group, a lower alkyl group or a lower alkoxy group; R₃ represents a lower alkoxy group; R₄, R₅, R₆, R₇, R₈ and R₉ each represent a hydrogen atom or a lower alkyl group; R₁₀ represents a hydrogen atom, a lower alkyl group, or a lower alkoxy group; and Y represents an oxygen atom or a methylene group; and Y being an oxygen atom when R₂ is a hydroxyl group, or the salts thereof which comprises reacting a compound represented by the formula ##STR103## wherein R represents a hydrogen atom or a lower alkyl group and R₁, R₂, R₄, R₅, R₆, R₇, R₈, R₉, R₁₀ and Y have the same significance as in the above formula with a halogenating agent fo form a halogenated product ##STR104## wherein X represents a chlorine atom or bromine atom and R and R₆ are hydrogen, reacting said halogenated product with an alkaline material and then reacting the product ##STR105## thus obtained with a lower alcohol.
 13. A process for producing sulfamoyl-substituted phenethylamine derivatives represented by the formula ##STR106## wherein R₁ represents an amino group or a mono- or di-lower alkylamino group; R₂ represents a hydroxyl group, a lower alkyl group or a lower alkoxy group; R₃ represents phenylthio; R₄, R₅, R₆, R₇, R₈ and R₉ each represent a hydrogen atom or a lower alkyl group; R₁₀ represents a hydrogen atom, a lower alkyl group, or a lower alkoxy group; and Y represents an oxygen atom or a methylene group; said Y being an oxygen atom when R₂ is a hydroxyl group, or the salts thereof which comprises reacting a compound represented by the formula ##STR107## wherein R represents a hydrogen atom or a lower alkyl group and R₁, R₂, R₄, R₅, R₆, R₇, R₈, R₉, R₁₀ and Y have the same significance as in the above formula with a halogenating agent to form a halogenated product ##STR108## wherein X represents a chlorine atom or bromine atom and R and R₆ are hydrogen, reacting said halogenated product with an alkaline material and then reacting the product ##STR109## thus obtained with thiophenol. 